After the death of Vanessa (Morena Baccarin), Wade Wilson (Ryan Reynolds) attempts suicide by blowing himself, but due to his healing abilities does not die. While recovering at X-Mansion, Wilson meets an unstable young mutant Russell Collins / Firefist who has supernatural abilities and lives at an orphanage. Cable (Josh Brolin), a time-travelling cybernetic soldier, travels back in time to kill Russell but Deadpool uses his powers to save him. But the foul-mouthed mutant mercenary realises that he alone can't deal with Cable, so he assembles a team of fellow powerful mutant rogues to protect the young boy from the brutal cyborg Cable and his advanced weaponry.